姓名：张月娟，副研究员

　　出生年月：1983.07

　　学历：博士

　　职称：副研究员

　　主要研究领域：

　　张月娟，副研究员，理学博士，中国微生物学会及陕西省生物化学学会会员，兼任Saudi Pharmaceutical Journal等期刊审稿人。主要研究方向包括(1)细菌抗生素耐药和β-内酰胺酶相关抑制剂筛选与评价;(2)基因工程蛋白的生产技术研究;(3)微胶囊制备工艺的研究。主持陕西省科技厅、陕西省科学院项目多项，参与国家自然科学基金、陕西省科学院等科研项目。在ACS Infectious Diseases，Frontier in Pharmacology等期刊发表第一作者或共同一作SCI论文6篇。

　　代表性成果(科研论文、授权发明专利等)：

　　(1) Y. J. Zhang, C. Chen, B. Cheng, L. Gao, C. Qin, L. X. Zhang, X. Zhang, J. Wang and Y. Wan*. Discovery of Quercetin and Its Analogs as Potent OXA-48 beta-Lactamase Inhibitors [J]. Frontier in Pharmacology, 2022 (已接收).

　　(2) Y. J. Zhang, W. M. Wang, P. Oelschlaeger, C. Chen, J. Lei, M. Lv and K. W. Yang*. Real-Time Monitoring of NDM-1 Activity in Live Bacterial Cells by Isothermal Titration Calorimetry: A New Approach to Measure Inhibition of Antibiotic-Resistant Bacteria [J]. ACS Infectious Diseases, 2018, 4, 1671-1678.

　　(3) Y. J. Zhang, K. Zhang, Y. Wan*, J. Zi, Y. Wang, J. Wang, L. L. Wang* and X. C. Xue. A pH-induced, Intein-mediated Expression and Purification of Recombinant Human Epidermal Growth Factor in Escherichia coli. Biotechnology progress, 2015, 31(3): 758-764.

　　(4) Y. J. Zhang, X. L. Liu, W. M. Wang, C. Chen, M. H. Zhao and K. W. Yang*. Amino Acid Thioesters Exhibit Inhibitory Activity against B1-B3 Subclasses of Metallo-beta-lactamases [J]. Chem Pharm Bull, 2019, 67, 135-142.

　　(5) Y. J. Zhang, L. Zhai, Y. Wan and K. W. Yang*. Triazolylthioacetamides Confer Inhibitory Efficacy against Metallo-β-Lactamase IMP-1 [J]. Letters in Drug Design & Discovery, 2020, 17, 76-84.

　　(6) S.Y. Wang, Y. J. Zhang, D. Gao, J. Zi, W. P Wang, N. Z Zhang, Y. Wan and L. L Wang. Refolding with simultaneous purification of recombinant core streptavidin using single-step high-performance hydrophobic interaction chromatography. Biotechnology and Bioprocess Engineering. 2019, 24: 658-665.