万一
姓名:万一
出生年月:1975年7月
学历:博士
职称:二级研究员
所内任职情况:所长,学术委员会主任,分子生物学研究中心主任,
人才称号:陕西省优秀青年科技新星、陕西省中青年科技领军人才
社会任职:国家重点研发计划重点专项项目负责人,“陕西省秦巴山区微生物资源发掘与利用工程技术中心”中心主任,陕西省科技创新团队带头人,中国生化制药工业协会SOD及生物抗氧化产业分会主任委员,陕西省微生物学会常务理事,陕西省天然药物学会常务理事,中国生物化学与分子生物学会工业生物化学与分子生物学分会理事,陕西省生物化学与分子生物学会理事
主要研究领域:秦岭、南北极等特色微生物资源的发掘及利用,功能微生物作用分子机制研究,高值化微生物产品的产业化开发。
代表性成果(科研论文、授权发明专利等):
[1] Yuejuan Zhang, Cheng Chen, Bin Cheng, Lei Gao, Chuan Qin , Lixia Zhang, Xu Zhang, Jun Wang1,2, Yi Wan1,2*.Discovery of Quercetin and Its Analogs as Potent OXA-48 Beta-Lactamase Inhibitors.Front. Pharmacol., 22 June 2022 | https://doi.org/10.3389/fphar.2022.926104
[2] Yan Wang, Mao Sun, Fan Chang, Jun Wang, Yan Wang*, Jie Tang, Kun Zhang,Lei Gao, Xiaochang Xue, Yi Wan*.The essential differences in microbial and chemical components of musk of different qualities secreted by captive male forest musk deer (Moschus berezovskii) [J]. Microbial Biotechnology.2022, doi:10.1111/1751-7915.14002.
[3] WANG J, ZHANG X, GAO L, WANG L, SONG F, ZHANG L, WAN Y*. The synergistic antifungal activity of resveratrol with azoles against Candida albicans[J]. Lett Appl Microbiol, 2021 Feb 6, doi: 10.1111/lam.13458.
[4]Wang Lu, Qiao Xinhua, Gao Lei, Chen Chang*, Wan Yi*. A quantitative method to assess bacterial adhesion using recombinant bioluminescent Pseudomonas aeruginosa. Biophysics Reports. 2021, 7(1): 55-70.
[5] 王军,张琨,张绪,刘柳,宁硕瀛,陈川,万一*. 秦巴山区虫生真菌的分离鉴定与多样性分析[J]. 西北农林科技大学学报(自然科学版), 2021(6): 2-9.
[6] HAN J*, YE N, ZHANG X, YU Z, WANG J, ZHANG Y, WAN Y*. Ligand-controlled self-assembly of Ag(I) complexes with cyano-containing ligands and their tunable antimicrobial activities[J]. Inorg Chim Acta, 2020, 512.
[7] 王军,李宏铎,张琨,高磊,万一*. 秦岭丹江流域黏细菌的分离及其代谢产物研究[J]. 西北农林科技大学学报(自然科学版), 2019, 47(10): 63-70, 79.
[8] WANG S, ZHANG Y, GAO D, ZI J, WANG W, ZHANG N, WAN Y*, WANG L*. Refolding with Simultaneous Purification of Recombinant Core Streptavidin Using Single-step High-performance Hydrophobic Interaction Chromatography[J]. Biotechnology and Bioprocess Engineering, 2019, 24(4): 658-665.
[9] 訾静,张月娟,万一*. 核心链霉亲和素在毕赤酵母中的表达及纯化[J]. 中国生物制品学杂志, 2018, 31(5): 485-488.
[10] ZHANG K, ZHANG Y, ZI J, XUE X*, WAN Y*. Production of Human Cu,Zn SOD with Higher Activity and Lower Toxicity in E. coli via Mutation of Free Cysteine Residues[J]. Biomed Res Int, 2017, 2017: 4817376.
[11] WANG Y, NIE M Q*, WAN Y*, TIAN X T, NIE H Y, ZI J, MA X. Functional characterization of two alkane hydroxylases in a versatile Pseudomonas aeruginosa strain NY3[J]. Ann Microbiol, 2017, 67(7): 459-468.
[12] ZHANG X, ZHANG S, WANG J, ZI J, WANG J, CHEN S*, WAN Y*. Expression, Purification, and Characterization of a Sucrose Nonfermenting 1-Related Protein Kinases 2 of Arabidopsis thaliana in E. coli-Based Cell-Free System[J]. Biomed Res Int, 2016, 2016: 9469356.
[13] YANG F#, WAN Y#, LIU J, YANG X, WANG H, TAO K, HAN J, SHI J*, HU D*. Expression and purification of rhIL-10-RGD from Escherichia coli as a potential wound healing agent[J]. J Microbiol Methods, 2016, 127: 62-67.
[14] GAO L, ZHANG Y, WANG Y, QIAO X, ZI J, CHEN C*, WAN Y*. Reduction of PCN biosynthesis by NO in Pseudomonas aeruginosa[J]. Redox Biol, 2016, 8: 252-258.
[15] 张琨,张月娟,万一*. 金黄色葡萄球菌肠毒素B的原核表达、纯化及鉴定[J]. 陕西师范大学学报(自然科学版), 2016, 44(6): 69-73.
[16] 张琨,王伟华,万一*,颜真,訾静,王军,高磊. 基于顺磁微粒的金黄色葡萄球菌肠毒素B免疫层析试纸条的制备[J]. 西北大学学报(自然科学版), 2016, 46(3): 403-407.
[17] ZHANG Y, ZHANG K, WAN Y*, ZI J, WANG Y, WANG J, WANG L*, XUE X. A pH-induced, intein-mediated expression and purification of recombinant human epidermal growth factor in Escherichia coli[J]. Biotechnol Prog, 2015, 31(3): 758-764.
[18] 万一*,訾静,张琨,张志敏,张月娟,王琰,王军. 金黄色葡萄球菌蛋白A(SpA)Z结构域串联体的克隆、表达和筛选[J]. 生物工程学报, 2012, 28(12): 1500-1510.
[19] WAN Y, YUAN S, XUE X, LI M, QIN X, ZHANG C, WANG W, JIANG C, WU S, LIU Y, ZHU W, RAN Y, ZHANG Z, HAN W*, ZHANG Y*. The preventive effect of adjuvant-free administration of TNF-PADRE autovaccine on collagen-II-induced rheumatoid arthritis in mice[J]. Cell Immunol, 2009, 258(1): 72-77.
[20] WAN Y, XUE X, LI M, ZHANG X, QIN X, ZHANG C, YOU Y, WANG W, JIANG C, WU S, LIU Y, ZHU W, RAN Y, ZHANG Z, HAN W, ZHANG Y*. Prepared and screened a modified TNF-alpha molecule as TNF-alpha autovaccine to treat LPS induced endotoxic shock and TNF-alpha induced cachexia in mouse[J]. Cell Immunol, 2007, 246(2): 55-64.
授权发明专利
[1] Yi Wan, Chang Chen, Lei Gao, Yuying Zhang, Xinhua Qiao, Yan Wang. Method, Target and Application for NO Accumulation to Decrease Pseudomonas Aeruginosa Invasiveness. US10537593,美国发明专利,专利出版公告日:2020年1月21日。
[2] Yi Wan, Chang Chen, Lei Gao, Yuying Zhang, Xinhua Qiao, Yan Wang, Method, Target and Application for NO Accumulation to Decrease Pseudomonas Aeruginosa Invasiveness[P]. US11058716 B2, 美国发明专利,专利出版公告日:2021年7月13日。
[3]万一,陈畅,高磊,张玉英,乔新华,王琰,NO累积降低铜绿假单胞菌侵袭力的方法、靶点及应用,中国,ZL201510697439.9
[4]万一,张琨,张月娟,王琰,一种提高重组人Cu,Zn-SOD活性蛋白产量的方法,2009.3.27,中国,ZL200910021725.8
[5]万一,张月娟,张琨,王琰,訾静,张志敏,王军,一种重组人表皮生长因子的新型制备方法,2012.6.5,中国,ZL201210181522.7
[6]万一,韩丽萍,沈卫荣,张月娟,孙晓宇,张琨,李玥,一种基于抗菌的双功能融合蛋白及其制备方法和用途,2009.10.26,中国,ZL200910209945.3
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